AMIDES OF ALPHA-AMINO ACIDS, THEIR SYNTHESIS AND THERAPEUTIC USE

AMIDES OF ALPHA-AMINO ACIDS, THEIR SYNTHESIS AND THERAPEUTIC USE

organic chemistry, amino acids. SUBSTANCE: invention relates to derivatives of serineamide, glycineamide, alanineamide and phenylalanineamide of the formula (I): where R is 1,2,3,4-tetrahydro-2-naphthalenyl or 2-indanyl that can be optionally substituted with lower alkyl, alkoxy-group or halogen ato...

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Hauptverfasser: ARMANI EHLIZABETTA, DEL'KANALE MAURITSIO, DE FANTI RENATO, VENTURA PAOLO, K'EZI PAOLO, VILLETTI DZHINO, P'ETRA KLAUDIO
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:organic chemistry, amino acids. SUBSTANCE: invention relates to derivatives of serineamide, glycineamide, alanineamide and phenylalanineamide of the formula (I): where R is 1,2,3,4-tetrahydro-2-naphthalenyl or 2-indanyl that can be optionally substituted with lower alkyl, alkoxy-group or halogen atom; R' is hydrogen atom, lower alkyl, phenyl-(lower)-alkyl; R1 is hydrogen atom, C1-C4-alkyl, optionally acylated C1-C4-hydroxyalkyl or phenyl-(lower)-alkyl; R2 is C1-C7-alkyl, phenyl-(lower)-alkyl. Invention describes also method of their synthesis from corresponding esters or amides of amino acids, pharmaceutical composition including compounds of the formula (I) as an active component. Compounds of the formula (I) are useful for treatment of patients with neurological diseases. EFFECT: improved method of synthesis, valuable medicinal properties. 7 cl, 3 tbl, 12 ex