14,17-C2-BRIDGE STEROIDS AND PHARMACEUTICAL PREPARATION

organic chemistry, pharmacy. SUBSTANCE: invention relates to 14,17-C2-bridge steroids of the formula (I) where R3 is O; R6 is H, alpha- or beta-C1-C4-alkyl and in this case R6 and R7 in common form additional bond; R7-alpha is beta-C1-C4- or R6- alkyl and in this case R6' and are both H, or R9 and R10 each means H or in common they form a bond; R11 and R12 each means H or in common they form a bond; R13 is CH3 or C2H5; R15 is H or C1-C3-alkyl; R16 and R16' mean independently H, C1-C3-alkyl or C1-C4-alkenyl or in common they form C1-C3-alkylidene; R15 and R16 in common form the cycle where n = 1; X is O and R16 is H; R17' is H, C1-C3-alkyl; R17 is H, C1-C3-alkyl; and each means H or in common they form a bond; R21 is H or C1-C3-alkyl; R21 is H, C1-C3-alkyl or OH with exception of 14,17-ethano-19- -norpregn-4-ene-3,20-dione. Compounds show very strong gestagenic activity and show effect on other steroid receptors that is used in pharmaceutical preparations. EFFECT: valuable medicinal properties of compounds. 11 cl