SUBSTITUTED PYRIMIDINETHIOALKYL OR ALKYLESTER COMPOUNDS AND METHOD OF INHIBITION OF VIRAL REVERSE TRANSCRIPTASE ACTIVITY

organic chemistry, biochemistry, virology. SUBSTANCE: invention relates to novel substituted pyrimidinethioalkyl or alkylester compounds, their pharmaceutically acceptable salts, hydrates, N-oxides and method of inhibition of viral reverse transcriptase activity. Proposed compounds can be used in tr...

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Bibliographische Detailangaben
Hauptverfasser:	DONN G. VISHKA, MAJKL DZH. MERFI, RICHARD A. N'JUDZHENT, RICHARD S. TOMAS, DEHVID R. GREJBER, STIVEN TOMAS SHLJAKHTER, GARI DZH. KLIK, DZHOEL MORRIS
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	organic chemistry, biochemistry, virology. SUBSTANCE: invention relates to novel substituted pyrimidinethioalkyl or alkylester compounds, their pharmaceutically acceptable salts, hydrates, N-oxides and method of inhibition of viral reverse transcriptase activity. Proposed compounds can be used in treatment of HIV-infected patients. Proposed compounds correspond to the general structural formula (I) where m = 0 or 1; R1 is taken among the group consisting of: -C=CH, -CO2R53, -CONR54R55 or residues of compounds of the formulas (A) , (B) and (C) where radical values are given in the invention claim. Method of inhibition of activity of viral reverse transcriptase involves administration to patients of effective dose of compound of the formula (I). EFFECT: new compounds indicated above, improved method of inhibition. 20 cl, 13 tbl