SMALL DI- AND TRIVALENT MOLECULES OF SELECTIN INHIBITORS, PHARMACEUTICAL COMPOSITION, METHOD OF SELECTING INHIBITION

organic chemistry, pharmacy. SUBSTANCE: invention relates to novel small di- and trivalent inhibitors of selectin of the formula (II) where X is taken among the group including -CN, -(CH2)nCO2H,-(CH2)n, CO-NH-OH, , -OH; Y is -(CH2)f; R1,R2 are taken independently among the group including hydrogen a...

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Bibliographische Detailangaben
Hauptverfasser:	TIMOTI P. KOGAN, JAN L. SKOTT, KHUONG BUI, KARIN M. KELLER, BRAJAN DJUPREH, DZHAMAL M. KASSIR, KEHTI L. VILER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	organic chemistry, pharmacy. SUBSTANCE: invention relates to novel small di- and trivalent inhibitors of selectin of the formula (II) where X is taken among the group including -CN, -(CH2)nCO2H,-(CH2)n, CO-NH-OH, , -OH; Y is -(CH2)f; R1,R2 are taken independently among the group including hydrogen atom, lower alkyl, halogen atom, -OZ, -NO2,-NH2; R3 is taken among the group including hydrogen atom, lower alkyl, hydroxy-lower alkyl, amino-lower alkyl, lower alkyl-carboxylic acid; f = 1-6; n = 0-2; b = 0-2; m = 1-3; Z means lower alkyl, phenyl, or to their pharmaceutically acceptable salts, esters, amides. Invention relates to also pharmaceutical composition based on new compounds and method of inhibition of E-selectin or P-selectin binding with sLex or sLea. EFFECT: new compounds indicated above, improved method of inhibition. 9 cl, 1 tbl, 10 ex