DERIVATIVES OF PYRIMIDINE- AND TRIAZINE CARBOXYLIC ACIDS FOR USE AS DRUGS

organic chemistry, pharmacy. SUBSTANCE: invention proposes a novel drug showing inhibitory properties with respect to endothelin receptors. Invention proposes derivatives of carboxylic acid of the general formula (I): where R means formyl group, carboxyl group or residue easily hydrolyzed to carboxy...

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Bibliographische Detailangaben
Hauptverfasser:	KHARTMUT RIKHERS, JOAKHIM RAJNKHAJMER, DAGMAR KLINGE, BURKKHARD KREGER, EHRNST BAUMANN, ZIGFRID BIALOJAN, LILIANE UNGER, UVE JOZEF FOGEL'BAKHER, KLAUS BOLL'SHVAJLER, MANFRED RASHAK, VOL'FGANG VERNET
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	organic chemistry, pharmacy. SUBSTANCE: invention proposes a novel drug showing inhibitory properties with respect to endothelin receptors. Invention proposes derivatives of carboxylic acid of the general formula (I): where R means formyl group, carboxyl group or residue easily hydrolyzed to carboxyl group; R2 and R3 means alkoxyl with carbon atoms number from 1 to 4; X means nitrogen atom or the group CH; R4,R5 and R6 means as given in the invention claim; Y means sulfur or oxygen atom; Z means oxygen atom. EFFECT: broadened arsenal of agents of indicated prescription. 4 tbl, 10 ex