METHOD OF PREPARING PHENYL HETEROCYCLES, AND INTERMEDIATE COMPOUND

METHOD OF PREPARING PHENYL HETEROCYCLES, AND INTERMEDIATE COMPOUND

medicine. SUBSTANCE: described is method of preparing compounds of formula I: wherein Ra and RB are hydrogen or halogen by reacting compound of formula wherein X2 is chlorine or bromine with compound of formula in solvent in the presence of base and transition metal-based catalyst to give compound o...

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Bibliographische Detailangaben
Hauptverfasser: RICHARD DEZMOND, BEN MEHRK'JUN, DEHVID CHEHN, RICHARD TILLAJER, UL'F DOLLING
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:medicine. SUBSTANCE: described is method of preparing compounds of formula I: wherein Ra and RB are hydrogen or halogen by reacting compound of formula wherein X2 is chlorine or bromine with compound of formula in solvent in the presence of base and transition metal-based catalyst to give compound of compound of formula which is oxidized to compound of formula I. Compounds of formula I are potent cyclooxihenase-2-inhibitors and are useful in medicine. EFFECT: more efficient preparation method. 15 cl, 2 ex