SULFAMATE DERIVATIVES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITIONS

pharmaceutical chemistry. SUBSTANCE: invention provides sulfamate derivatives of 1,3,5(10)-extratriene derivatives having general formula I: (I), in which R1 is -COR3,-COOR4,-CONR5R6,-SO2R4, or -SO2NR5R6 wherein R3 and R4 independently denote C1-C5-alkyl, C3-C5-cycloalkyl, or phenyl, and R5 and R6 i...

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Hauptverfasser: GUDRUN REDDERSEN, MARGIT RIKHTER, INA TIME, BIRGITT SHNAJDER, ZIGFRID SHVARTS, VAL'TER EHL'GER
Format: Patent
Sprache:eng ; rus
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Zusammenfassung:pharmaceutical chemistry. SUBSTANCE: invention provides sulfamate derivatives of 1,3,5(10)-extratriene derivatives having general formula I: (I), in which R1 is -COR3,-COOR4,-CONR5R6,-SO2R4, or -SO2NR5R6 wherein R3 and R4 independently denote C1-C5-alkyl, C3-C5-cycloalkyl, or phenyl, and R5 and R6 independently denote C1-C5-alkyl; R2 is hydrogen atom or C1-C5-alkyl; R7 and R8, independently from each other, are hydrogen atom or alkoxy group; R9 and R10 are hydrogen atom or, together with each other, form one methylene group; R11,R12, and R13, independently from each other, are hydrogen or hydroxyl group optionally esterified by physiologically acceptable inorganic or organic acids, or R12 and R13 are alkynyl with up to 5 carbon atoms, provided that R8,R11, and R12, independently from each other, are located in alpha- or beta positions. Compounds I show estrogenic activity. EFFECT: extended assortment of estrogenic preparations. 26 cl, 2 tbl