1,2,3-TRIAZOLYL)-1,2,3-OXADIAZOLE DERIVATIVES POTENTIATING NO-DEPENDENT ACTIVATION OF SOLUBLE FORM OF GUANYLATE CYCLAZE

chemical industry. SUBSTANCE: described are new chemical compounds, more particularly (1,2,3-triazolyl)-1,2,5-oxadiazole derivatives of general formula I wherein R is NH1 or , and if R1 is H, then R2 is lower hydroxyalkyl, or if R1 is lower alkyl, lower hydroxyalkyl, aryl, then R2 is H, lower hydrox...

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Bibliographische Detailangaben
Hauptverfasser:	BATOG L.V, SEVERINA I.S, KHROPOV JU.V, BUSYGINA O.G, MAKHOVA N.N, ROZHKOV V.JU, PJATAKOVA N.V
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	chemical industry. SUBSTANCE: described are new chemical compounds, more particularly (1,2,3-triazolyl)-1,2,5-oxadiazole derivatives of general formula I wherein R is NH1 or , and if R1 is H, then R2 is lower hydroxyalkyl, or if R1 is lower alkyl, lower hydroxyalkyl, aryl, then R2 is H, lower hydroxyalkyl or radical of general formula: -C(O)R3 wherein R3 is OH, NH2 lower alkyl or lower alkoxy. Said derivatives potentiate NO-dependent activation of soluble form of p guanylate cyclaze. Said 1,2,3-triazol-1-yl)- 1,2,3-oxadiazole derivatives produce selective potentiating effect on NO-dependent activation of soluble form of p guanylate cyclaze, widen range of specific regulators of activity of soluble form of p guanylate cyclaze. EFFECT: improved properties of the title compounds. 14 cl, 1 tbl