DERIVATIVES OF PHENYLCYCLOHEXYLCARBOXYLIC ACID AMIDE, MIXTURE OF THEIR OR SEPARATE ISOMERS AND THEIR SALTS, PHARMACEUTICAL COMPOSITION WITH ANTIARTERIOSCLEROTIC AND ANTIRESTENOSIS ACTIVITY

organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of phenylcyclohexylcarboxylic acid amide of the general formula (I) where D is the group -CH- or nitrogen atom; R1 is phenyl, cycloalkyl with 3-6 carbon atoms, direct or branched alkyl with 1-5 carbon atoms; R2 is direct or bra...

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Hauptverfasser:	SHTEFAN VOL'FAJL', MATTIAS MJULLER-GLIMANN, SHTEFAN LOMER, ETSKAN JALKINOGLU, UL'RIKH MJULLER, DIRK DENTSER, MARTIN BOJK, RUDI GRJUTTSMANN, ZIGFRID TSAJSS, ANKE DOMDAJ-BETTE, KRISTOF GERDES, DZHEJMS EHL'TING
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of phenylcyclohexylcarboxylic acid amide of the general formula (I) where D is the group -CH- or nitrogen atom; R1 is phenyl, cycloalkyl with 3-6 carbon atoms, direct or branched alkyl with 1-5 carbon atoms; R2 is direct or branched alkoxycarbonyl with 1-5 carbon atoms or residue of the formula -CO-NH2 or -CH2--OH, mixture of their isomers or separate isomers and their salts. Invention relates to also pharmaceutical composition based on compounds indicated above showing antiarteriosclerotic and antirestenosis activities. EFFECT: valuable medicinal properties of compounds. 5 cl, 3 tbl, 8 ex