DERIVATIVES OF 4-ARYL-6-AMINONICOTINIC ACID AND THEIR SALTS
organic chemistry. SUBSTANCE: invention relates to derivatives of 4-aryl-6-aminonicotinic acid of the formula (I) and their salts where A is unsubstituted phenyl or phenyl substituted with 1-3 similar or different residues from the group involving nitro-, cyano-group, phenyl, halogen atom and triflu...
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| creator | KHANS-GEORG KHEJNE TOMAS GLAZER ZHAN-MARI-VIKTOR DE VRI BODO JUNGE REJLINDE VITTKA ZIGFRID GOL'DMANN KHENNING ZOMMERMEJER KLAUS URBANS RUDOL'F SHOKHE-LOOP |
| description | organic chemistry. SUBSTANCE: invention relates to derivatives of 4-aryl-6-aminonicotinic acid of the formula (I) and their salts where A is unsubstituted phenyl or phenyl substituted with 1-3 similar or different residues from the group involving nitro-, cyano-group, phenyl, halogen atom and trifluoromethyl-group or direct or branched alkylthio-group with 1-6 carbon atoms, or direct or branched alkoxyl with 1-6 carbon atoms, D-cyano- or nitro-group; R1 is hydrogen atom or C1-8-alkyl; R2 and R3 mean hydrogen atom, C1-6-alkyl, C1-6-acyl at condition that if A means unsubstituted phenyl or phenyl substituted with chlorine atom, methoxyl or nitro-group, D-cyano-group at position 4 and R2 and R3 mean hydrogen atom then R1 does not mean ethyl. Compounds of the formula (I) can be used in medicine as modulators of potassium channels. EFFECT: valuable pharmacological properties of compounds. 3 cl, 6 tbl, 34 ex |
| format | Patent |
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SUBSTANCE: invention relates to derivatives of 4-aryl-6-aminonicotinic acid of the formula (I) and their salts where A is unsubstituted phenyl or phenyl substituted with 1-3 similar or different residues from the group involving nitro-, cyano-group, phenyl, halogen atom and trifluoromethyl-group or direct or branched alkylthio-group with 1-6 carbon atoms, or direct or branched alkoxyl with 1-6 carbon atoms, D-cyano- or nitro-group; R1 is hydrogen atom or C1-8-alkyl; R2 and R3 mean hydrogen atom, C1-6-alkyl, C1-6-acyl at condition that if A means unsubstituted phenyl or phenyl substituted with chlorine atom, methoxyl or nitro-group, D-cyano-group at position 4 and R2 and R3 mean hydrogen atom then R1 does not mean ethyl. Compounds of the formula (I) can be used in medicine as modulators of potassium channels. 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SUBSTANCE: invention relates to derivatives of 4-aryl-6-aminonicotinic acid of the formula (I) and their salts where A is unsubstituted phenyl or phenyl substituted with 1-3 similar or different residues from the group involving nitro-, cyano-group, phenyl, halogen atom and trifluoromethyl-group or direct or branched alkylthio-group with 1-6 carbon atoms, or direct or branched alkoxyl with 1-6 carbon atoms, D-cyano- or nitro-group; R1 is hydrogen atom or C1-8-alkyl; R2 and R3 mean hydrogen atom, C1-6-alkyl, C1-6-acyl at condition that if A means unsubstituted phenyl or phenyl substituted with chlorine atom, methoxyl or nitro-group, D-cyano-group at position 4 and R2 and R3 mean hydrogen atom then R1 does not mean ethyl. Compounds of the formula (I) can be used in medicine as modulators of potassium channels. EFFECT: valuable pharmacological properties of compounds. 3 cl, 6 tbl, 34 ex</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVATIVES OF 4-ARYL-6-AMINONICOTINIC ACID AND THEIR SALTS |
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