DERIVATIVES OF 4-ARYL-6-AMINONICOTINIC ACID AND THEIR SALTS

organic chemistry. SUBSTANCE: invention relates to derivatives of 4-aryl-6-aminonicotinic acid of the formula (I) and their salts where A is unsubstituted phenyl or phenyl substituted with 1-3 similar or different residues from the group involving nitro-, cyano-group, phenyl, halogen atom and triflu...

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Bibliographische Detailangaben
Hauptverfasser:	KHANS-GEORG KHEJNE, TOMAS GLAZER, ZHAN-MARI-VIKTOR DE VRI, BODO JUNGE, REJLINDE VITTKA, ZIGFRID GOL'DMANN, KHENNING ZOMMERMEJER, KLAUS URBANS, RUDOL'F SHOKHE-LOOP
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	organic chemistry. SUBSTANCE: invention relates to derivatives of 4-aryl-6-aminonicotinic acid of the formula (I) and their salts where A is unsubstituted phenyl or phenyl substituted with 1-3 similar or different residues from the group involving nitro-, cyano-group, phenyl, halogen atom and trifluoromethyl-group or direct or branched alkylthio-group with 1-6 carbon atoms, or direct or branched alkoxyl with 1-6 carbon atoms, D-cyano- or nitro-group; R1 is hydrogen atom or C1-8-alkyl; R2 and R3 mean hydrogen atom, C1-6-alkyl, C1-6-acyl at condition that if A means unsubstituted phenyl or phenyl substituted with chlorine atom, methoxyl or nitro-group, D-cyano-group at position 4 and R2 and R3 mean hydrogen atom then R1 does not mean ethyl. Compounds of the formula (I) can be used in medicine as modulators of potassium channels. EFFECT: valuable pharmacological properties of compounds. 3 cl, 6 tbl, 34 ex