WATER-SOLUBLE NIMESULID AND L-LYSINE SALT, METHOD OF ITS PREPARING, COMPOSITION BASED ON THEREOF, NIMESULID SALT AQUEOUS SOLUTION, PHARMACEUTICAL COMPOSITION WITH ANTI-INFLAMMATORY ACTIVITY

pharmacy. SUBSTANCE: invention claims water-soluble nimesulid and L-lysine salt formed as product of reaction between nimesulid and L-lysine with anti-inflammatory activity. Method of its preparing involves dissolution of nimesulid and L-lysine in methanol followed by separation of formed salt from...

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Bibliographische Detailangaben
Hauptverfasser:	PIEL' ZHERAL'DIN, ZHESZI ZHOZEF, PIROTT BERNAR, DEL'NEVIJ IZABEL', NEVEN FILIPP
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY COMPOSITIONS BASED THEREON COMPOSITIONS OF MACROMOLECULAR COMPOUNDS DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY ORGANIC MACROMOLECULAR COMPOUNDS POLYSACCHARIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:	pharmacy. SUBSTANCE: invention claims water-soluble nimesulid and L-lysine salt formed as product of reaction between nimesulid and L-lysine with anti-inflammatory activity. Method of its preparing involves dissolution of nimesulid and L-lysine in methanol followed by separation of formed salt from methanol and/or concentrating by evaporation. Invention proposes also compositions with anti-inflammatory activity based on nimesulid with cyclodextrin. Invention describes nimesulid salt aqueous solution and pharmaceutical composition with anti-inflammatory activity. EFFECT: improved method of salt preparing. 17 cl, 28 dwg, 6 tbl, 15 ex