METHODS AND COMBINATIONS CONTAINING DNA-AFFECTING AGENTS AND P53

FIELD: medicine. SUBSTANCE: method involves applying malignant tumor gene- suppressor agents in combination with a DNA-affecting agents or factor to kill cells being in particular cases malignant tumor cells. Malignant tumor gene-suppressor p53 is in vivo delivered by a gene-carrier with adenovirus...

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Hauptverfasser:	FUDZIVARA TOSIJOSI, GRIMM EHLIZABET A, OUVEN-SHOB LORI B, ROT DZHEK A, MUKHOPAD'JAJ TAPAS, SHANG VEJ-VEJ
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Zusammenfassung:	FIELD: medicine. SUBSTANCE: method involves applying malignant tumor gene- suppressor agents in combination with a DNA-affecting agents or factor to kill cells being in particular cases malignant tumor cells. Malignant tumor gene-suppressor p53 is in vivo delivered by a gene-carrier with adenovirus recombinant as intermediate stage in combination with a chemotherapeutic agent. Treated cells show apoptosis state with specific DNA-fragmentation. Direct subcutaneous injection of a p53-adenovirus formulation into malignant tumors with following DNA-affecting agent like cis-platinum intraperitoneal administration causes general scale apoptotic tumor destruction. The method also involves causing gene displacement due to replication-defective adenovirus p53 of wild-nature type being applied in combination with DNA-affecting agents for treating the cases of malignant tumors. EFFECT: enhanced effectiveness of treatment. 115 cl, 45 dwg