3,4,4-TRISUBSTITUTED PIPERIDINYL-N-ALKYLCARBOXYLATES AND INTERMEDIATE COMPOUNDS, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel crystalline ester of (alphaS, 3R, 4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-alpha-(phenyl- -methyl)-1-piperidine propionic acid of the formula where R is C1-C6-alkyl; Z - the group taken among hydrochloride, hydrobromide, succin...

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Bibliographische Detailangaben
Hauptverfasser:	SKOTT ALAN FREHNK, DUGLAS EHDVARD PRETER, DZHEFFRI ALAN UORD, DZHON ARNOL'D VERNER
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel crystalline ester of (alphaS, 3R, 4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-alpha-(phenyl- -methyl)-1-piperidine propionic acid of the formula where R is C1-C6-alkyl; Z - the group taken among hydrochloride, hydrobromide, succinate and (+)-dibenzoyl tartrate that can be used for binding the specific receptor in patient. Compound is used for treatment of patients with irritable bowel syndrome, idiopathic constipation and nonulcer dyspepsia. EFFECT: improved method of synthesis, valuable pharmacological properties. 12 cl, 9 tbl, 8 ex