PEPTIDE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, METHOD OF THEIR SYNTHESIS, USE AND PHARMACEUTICAL COMPOSITION

FIELD: chemistry of peptides, pharmacy. SUBSTANCE: invention relates to peptides of the general formula (I): R1-CH2-CH2-CONH--CH(R2)CH2R3 or their pharmaceutically acceptable salts where R1 means hydrogen atom or hydrocarbon C1-C3-radical substituted with the functional group, for example, amino, amide with C1-C5-radical, C1-C7-urethane or carboxy-group or hydrocarbon C1-C3-radical substituted simultaneously with amino- or carboxy-group; carboxy-group can be esterified and amino-group can be substituted with acyl substituent or carbonic acid ester; R2 means hydrogen atom or the functional group, for example, carboxyl that can be esterified; R3 means indole or its methyl and/or hydroxyl derivatives being hydroxyl group can be acylated, alkylated or aralkylated, 5-6-membered saturated and unsaturated cyclic and heterocyclic substituents containing oxygen, sulfur and/or 1-3 nitrogen atoms or their methyl derivatives; if R1 is NH2,NH2-CH2- and R2 is H then R3 does not mean -4-Im, -3-(5-OMe-Ind), -3-(5-OH-Ind); if R1 means NH2,NH2-CH2- and R2 means COOH then R3 does not mean -4-Im and if R1 means HOOC-CH(NH2)- and R2 means H then R3 does not mean -3-Ind, -3-(5-OH-Ind). Compounds (I) show properties of modulators of cytochrome P-420 system, metabolism of arachidonic acid, adrenal cortex hormones, macrophage activity and an antioxidant, antihypoxic, antiviral, lipid-regulating, antimetastatic, glucose-decreasing, adaptogenic and other kinds of therapeutic effect. Compounds of the formula (I) are synthesized by acylation of amino-group in the compound (II): NH2-CH-(R2)-CH2-R3 with a carboxyl component: R1-CH2-CH2-COX where X is an activating group. EFFECT: improved me