DERIVATIVES OF 1-BENZENESULFONYL-1,3-DIHYDROINDOLE-2-ON'E, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 1-benzene-sulfonyl-1,3-dihydroindole-2-on'e of the general formula (I) where R1 - halogen atom, trifluoromethyl or C1-7-alkoxyl; R3,R4 - sigma-hydroxyalkyl where hydroxyl is substituted possibly with alkyl, tetra...

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Hauptverfasser:	ZHORZH GARSIA, ZHAN VAN'ON, RISHAR RU, LOIK FULON, DINO NIZATO, ALENMAL'TA, KLODIN SERRADEJ-LEGAL, ZHERAR VALETT
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 1-benzene-sulfonyl-1,3-dihydroindole-2-on'e of the general formula (I) where R1 - halogen atom, trifluoromethyl or C1-7-alkoxyl; R3,R4 - sigma-hydroxyalkyl where hydroxyl is substituted possibly with alkyl, tetrahydrofuranyl or tetrahydropyranyl; or R3,R4 in common form the group -(CH2)pX(CH2)q-; or R3,R4 in common with carbon atom to which they are bound form hydrocarbon C3-12-cycle (possibly condensed), possibly substituted with alkyl, oxo-group, 1-2 hydroxyls; R5 is C1-7-alkoxyl; R6 is guanidine radical (other values see in p. 1 of the invention claim) and also their possible salts that show affinity to vasopressin and/or oxytocin receptors. EFFECT: improved method of synthesis, valuable pharmacological properties. 11 cl, 7 tbl, 83 ex