POLYMER-ASSISTED AMPLIFICATION OF VITAMIN B12 ABSORPTION SYSTEM

POLYMER-ASSISTED AMPLIFICATION OF VITAMIN B12 ABSORPTION SYSTEM

FIELD: pharmaceutical chemistry. SUBSTANCE: invention relates to orally supplying peptide and protein pharmaceutics involving vitamin B12 absorption system amplified by polymers. In particular, complex is utilized, wherein Y denotes carrier to be bound to natural internal factor: vitamin B or its an...

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Bibliographische Detailangaben
Hauptverfasser: GREGORI DZHON RASSELL-DZHONS, BERNARD VINSENT MAKAJNERNI, STIVEN UILL'JAM VESTVUD, ALISON RAT GOULD
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:FIELD: pharmaceutical chemistry. SUBSTANCE: invention relates to orally supplying peptide and protein pharmaceutics involving vitamin B12 absorption system amplified by polymers. In particular, complex is utilized, wherein Y denotes carrier to be bound to natural internal factor: vitamin B or its analog, n is coefficient of molar substitution of Y in complex and ranges from 1.0 to approximately 10; P denotes pharmaceutically acceptable polymer; A pharmaceutically active substance; m is coefficient of molar substitution of A in complex and ranges from 1.0 to approximately 1000; O and O', independently, denote covalent bond or spacer compound connecting Y, P, and A by covalent linkages. EFFECT: improved oral supply of pharmaceutics. 38 cl, 6 ex