H- AND L-CHAINS OF MONOCLONAL ANTIBODY PM-1 (MONAT) TO HUMAN IL-6R RECEPTOR AND THEIR V-REGION, MODIFIED MONAT, ITS H- AND L-CHAINS AND THEIR V-REGIONS, CDR-SEQUENCE, DNA-SEQUENCE

FIELD: biotechnology, immunology. SUBSTANCE: invention relates to the V-region of L-chain of murine monoclonal antibodies to human IL-6R and H-chain of V-region of murine monoclonal antibodies to human IL-6R. Also, modified antibodies to human IL-6R, DNA-sequence encoding the above indicated antibod...

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Bibliographische Detailangaben
Hauptverfasser:	KOKH SATO, ZHOZE UIL'JAM SALDANKHA, MASAJUKI TSUTIJA, MEHRI MARGARET BENDIG, STIVEN TARRAN DZHONS
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology, immunology. SUBSTANCE: invention relates to the V-region of L-chain of murine monoclonal antibodies to human IL-6R and H-chain of V-region of murine monoclonal antibodies to human IL-6R. Also, modified antibodies to human IL-6R, DNA-sequence encoding the above indicated antibodies or their fragments are given. Antibodies to human IL-6R receptors can be used as a therapeutic agent for treatment of patients with myeloma. EFFECT: antibodies as the medicinal preparation. 24 cl, 24 dwg, 9 tbl, 17 ex