DERIVATIVES OF BIS-NAPHTHALIMIDE AND THEIR PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALTS, PHARMACEUTICAL COMPOSITION SHOWING CYTOTOXIC ACTIVITY CONTAINING THEREOF

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new derivatives of bis-naphthalimide of the general formula (I) where X, X', X'' and X''' are identical or different and taken among the group including hydrogen atom, nitro-, amino-group, NH-lower acyl...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: KINDZIA ROMERDAL, KHOSE MARIJA KASTELLANO BERLANGA, KSIAO-DONG KVIAN, PITER BUSKET, MARINA MORAN MOSET, MIGEL' FERNANDEZ BRAN'JA, MARIJA KHESUS PEREZ DEH VEGA, GERKHARD KAJL'KHAUER
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new derivatives of bis-naphthalimide of the general formula (I) where X, X', X'' and X''' are identical or different and taken among the group including hydrogen atom, nitro-, amino-group, NH-lower acyl, hydroxyl, halogen atom, alkyl with 1-6 carbon atoms, or X and X' or X'' and X''' can form ethylene bridge bound with carbon atoms at positions 4 and 5 of cyclic system; R and R' - H, alkyl with 1-4 carbon atoms; A and D are similar or different and mean the group -CH2-CH2- that can be substituted with alkyl with 1-4 carbon atoms; B - the group -(CH2)n- where n = 3 or 4 and where one hydrogen atom can be substituted with alkyl group with 1-4 carbon atoms, and their pharmaceutically acceptable acid-additive salts. Described compounds show cytotoxic activity. Invention describes also a pharmaceutical composition based on compounds of the formula (I) showing cytotoxic activity. EFFECT: new compounds indicated above, cytotoxic activity. 6 cl, 18 ex