DERIVATIVES OF 3-(5-TETRAZOLYLBENZYL)-AMINOPIPERIDINE, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION ON SAID

DERIVATIVES OF 3-(5-TETRAZOLYLBENZYL)-AMINOPIPERIDINE, METHODS OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION ON SAID

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 3-(5-tetrazolylbenzyl)-aminopiperidine of the formula (I) where R is C1-4-alkoxy-group; R - a residue of the formula (a); R - H or halogen atom; R4, R - H, halogen atom, C1-4-alkyl, C1-4-alkoxy-group, CF3; R - H, C1-4...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GIBLIN DZHERARD MARTIN POL, ARMUR DANKAN ROBERT, NEHJLOR ALAN, PEGG NIL EHNTONI, MIDLMISS DEJVID, UOTSON STIVEN POL, KHABBARD TANJA, VAJNEJDER MARIJA VIKTORIJA, KHEHNN MAJKL MENTEHJT, LJUEHLL ZJAO-KING, EHVANS BRAJAN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 3-(5-tetrazolylbenzyl)-aminopiperidine of the formula (I) where R is C1-4-alkoxy-group; R - a residue of the formula (a); R - H or halogen atom; R4, R - H, halogen atom, C1-4-alkyl, C1-4-alkoxy-group, CF3; R - H, C1-4-alkyl, (CH2)m-cyclopropyl, -S(O)nC1-4-alkyl, phenyl, NR7R8, CH2C(O)CF3 or CF3; R7, R - H, C1-4-alkyl or acyl; x = 0 or 1; n = 0, 1 or 2; m = 0 or 1, or their pharmaceutically acceptable salts or solvates which are strong and specific antagonists of tachykinins including P-substance and other neurokinins. EFFECT: improved method of synthesis, antagonists of tachykinins. 22 cl, 1 dwg, 45 ex