DERIVATIVES OF PREDNISOLONE, METHOD OF THEIR SYNTHESIS AND DRUG

FIELD: organic chemistry, steroids, pharmacy. SUBSTANCE: invention relates to derivatives of prednisolone of the general formulas (I) , (Ia) and (Ib) showing effectiveness for treatment and prophylaxis of skin and upper respiratory way diseases. Compounds of the formula (I) are synthesized by intera...

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Bibliographische Detailangaben
Hauptverfasser:	ROL'F BOJME, DITER FLOKERTSI, MIKHAEHL' SHTOEK, KARL TSEKH, BEATE GUTTERER, KHERMANN AMSHLER, STEFAN POSTIUS, RIKHARD RIDEL
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry, steroids, pharmacy. SUBSTANCE: invention relates to derivatives of prednisolone of the general formulas (I) , (Ia) and (Ib) showing effectiveness for treatment and prophylaxis of skin and upper respiratory way diseases. Compounds of the formula (I) are synthesized by interaction of 16-hydroxyprednisolone with cyclohexane aldehyde. EFFECT: improved method of synthesis, enhanced effectiveness of treatment and prophylaxis. 9 cl, 1 tbl, 17 ex