DERIVATIVES OF PIPERIDINE AND PIPERAZINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS CONTAINING ON SAID AND METHOD OF THEIR PREPARING

DERIVATIVES OF PIPERIDINE AND PIPERAZINE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITIONS CONTAINING ON SAID AND METHOD OF THEIR PREPARING

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of piperidine and piperazine of the formula (I) where Ind is indole-3-yl residue that can be substituted once with groups OH, OA, CN or COR ; R is benzofuran, 2,3-dihydrofuran-5-yl, chroman-6-yl possibly substituted once...

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Hauptverfasser: GERD BARTOSHIK, KRISTOF ZEJFRID, KHARTMUT GRAJNER, KHENNING BETTKHER
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of piperidine and piperazine of the formula (I) where Ind is indole-3-yl residue that can be substituted once with groups OH, OA, CN or COR ; R is benzofuran, 2,3-dihydrofuran-5-yl, chroman-6-yl possibly substituted once with CH2OH or COR ; Q is CmH2m; Z is N or CR ; A is C1-6-alkyl; R is OH, OA, NH2; m = 2, 3, 4 and their physiologically acceptable salts showing also effect on the central nervous system and firstly on 5-HT1A-agonistic and 5-HT-reuptake-inhibiting effects. EFFECT: improved method of synthesis, centrally acting compounds. 5 cl, 1 tbl, 11 ex