DOLOSTATINE ANALOG

FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to peptides of the general formula (I) where R is C1-7-alkyl; R is C1-4-alkyl; X is C1-5-alkyl; R is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the...

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Hauptverfasser:	DAGMAR KLINGE, KURT RITTER, KSIAO-DONG KVIAN, ANDREAS KHAUPT, SINTIJA ROMERDAL, BERND JANSSEN, GERKHARD KEJL'KHAUER, TEREZA BARLOZZARI
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Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	DAGMAR KLINGE KURT RITTER KSIAO-DONG KVIAN ANDREAS KHAUPT SINTIJA ROMERDAL BERND JANSSEN GERKHARD KEJL'KHAUER TEREZA BARLOZZARI
description	FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to peptides of the general formula (I) where R is C1-7-alkyl; R is C1-4-alkyl; X is C1-5-alkyl; R is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. EFFECT: improved therapeutic properties. 2 cl, 2 tbl, 2 ex
format	Patent
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SUBSTANCE: invention relates to peptides of the general formula (I) where R is C1-7-alkyl; R is C1-4-alkyl; X is C1-5-alkyl; R is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. 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SUBSTANCE: invention relates to peptides of the general formula (I) where R is C1-7-alkyl; R is C1-4-alkyl; X is C1-5-alkyl; R is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. 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SUBSTANCE: invention relates to peptides of the general formula (I) where R is C1-7-alkyl; R is C1-4-alkyl; X is C1-5-alkyl; R is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. EFFECT: improved therapeutic properties. 2 cl, 2 tbl, 2 ex</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	DOLOSTATINE ANALOG
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