DOLOSTATINE ANALOG

DOLOSTATINE ANALOG

FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to peptides of the general formula (I) where R is C1-7-alkyl; R is C1-4-alkyl; X is C1-5-alkyl; R is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the...

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Bibliographische Detailangaben
Hauptverfasser: DAGMAR KLINGE, KURT RITTER, KSIAO-DONG KVIAN, ANDREAS KHAUPT, SINTIJA ROMERDAL, BERND JANSSEN, GERKHARD KEJL'KHAUER, TEREZA BARLOZZARI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to peptides of the general formula (I) where R is C1-7-alkyl; R is C1-4-alkyl; X is C1-5-alkyl; R is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R - H; R - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. EFFECT: improved therapeutic properties. 2 cl, 2 tbl, 2 ex