THIOFORMAMIDE DERIVATIVES OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS

THIOFORMAMIDE DERIVATIVES OR THEIR PHARMACOLOGICALLY ACCEPTABLE SALTS

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of thioformamide of the general formula (I) where Y - a group of the formula -C(O)-, -CH(OH)-, =N-O-Ph, O=C(Ph)-O ; Z means ; A means substituted or nonsubstituted imidazopyridyl; R1, R2, R and R - hydrogen or lower alky...

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Hauptverfasser: KEJDZI ISIBASI, NOBUJUKI MORI, KHITOSI OJNUMA, KHIDEJUKI ADATI, KHIDETO OKHARA, KHIROSI KATO, NORIO MINAMI, TOSIAKI OGAVA, KOKHTARO KODAMA, FUMIKHIRO OZAKI, TAKASI KHASEGAVA, JASUKHIRO KABASAVA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of thioformamide of the general formula (I) where Y - a group of the formula -C(O)-, -CH(OH)-, =N-O-Ph, O=C(Ph)-O ; Z means ; A means substituted or nonsubstituted imidazopyridyl; R1, R2, R and R - hydrogen or lower alkyl, or their pharmaceutically acceptable salts exhibiting high hypotensive properties. EFFECT: improved method of synthesis, enhanced pharmacological activity of compounds. 6 cl, 24 ex, 1 tbl