METHOD OF OLIGONUCLEOTIDE DUPLEX STABILIZATION
FIELD: molecular biology, pharmacology. SUBSTANCE: invention proposes an interaction of oligodeoxyribonucleotide conjugates with small-groove ligands. Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsen...
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| creator | LOKHOV S.G RJABININ V.A SINJAKOV A.N |
| description | FIELD: molecular biology, pharmacology. SUBSTANCE: invention proposes an interaction of oligodeoxyribonucleotide conjugates with small-groove ligands. Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsense" preparations. EFFECT: improved method of stabilization. 2 cl, 3 dwg, 1 tbl, 12 ex |
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Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsense" preparations. EFFECT: improved method of stabilization. 2 cl, 3 dwg, 1 tbl, 12 ex</description><edition>6</edition><language>eng ; rus</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SUGARS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990110&DB=EPODOC&CC=RU&NR=2124523C1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990110&DB=EPODOC&CC=RU&NR=2124523C1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOKHOV S.G</creatorcontrib><creatorcontrib>RJABININ V.A</creatorcontrib><creatorcontrib>SINJAKOV A.N</creatorcontrib><title>METHOD OF OLIGONUCLEOTIDE DUPLEX STABILIZATION</title><description>FIELD: molecular biology, pharmacology. SUBSTANCE: invention proposes an interaction of oligodeoxyribonucleotide conjugates with small-groove ligands. Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsense" preparations. 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SUBSTANCE: invention proposes an interaction of oligodeoxyribonucleotide conjugates with small-groove ligands. Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsense" preparations. EFFECT: improved method of stabilization. 2 cl, 3 dwg, 1 tbl, 12 ex</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS |
| title | METHOD OF OLIGONUCLEOTIDE DUPLEX STABILIZATION |
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