METHOD OF OLIGONUCLEOTIDE DUPLEX STABILIZATION

FIELD: molecular biology, pharmacology. SUBSTANCE: invention proposes an interaction of oligodeoxyribonucleotide conjugates with small-groove ligands. Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsen...

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Bibliographische Detailangaben
Hauptverfasser:	LOKHOV S.G, RJABININ V.A, SINJAKOV A.N
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SUGARS
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Beschreibung
Zusammenfassung:	FIELD: molecular biology, pharmacology. SUBSTANCE: invention proposes an interaction of oligodeoxyribonucleotide conjugates with small-groove ligands. Stabilized duplexes can be used in hybridous diagnosis to increase a sensitivity threshold of a method and in medicine as antigenous and "nonsense" preparations. EFFECT: improved method of stabilization. 2 cl, 3 dwg, 1 tbl, 12 ex