GLYCOPEPTIDE FULLERENE DERIVATIVE SHOWING ADJUVANT ACTIVITY

FIELD: medicine, biotechnology, veterinary science. SUBSTANCE: invention proposes a fullerene derivative of glycopeptide of the formula (I): GlcNAc-MurNAc-Ala-D-iGln--[Lys-e-CO(CH2)5NHC6O-H], showing adjuvant activity. Substance is obtained by synthesis of aminocaproic acid fullerene derivative and...

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Bibliographische Detailangaben
Hauptverfasser:	VOL'PINA O.M, ANDRONOVA T.M, KUPRIJANOVA M.A, ROMANOVA V.S, IVANOV V.T, ZHMAK M.N, VOL'PIN M.E, MAKAROV E.A, PARNES Z.N
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	FIELD: medicine, biotechnology, veterinary science. SUBSTANCE: invention proposes a fullerene derivative of glycopeptide of the formula (I): GlcNAc-MurNAc-Ala-D-iGln--[Lys-e-CO(CH2)5NHC6O-H], showing adjuvant activity. Substance is obtained by synthesis of aminocaproic acid fullerene derivative and the following its addition reaction to glycopeptide lysine derivative. Synthesized compound shows high adjuvant property at low doses (1-10 nM per an animal). At high dose (1 mg/mouse) this substance does not show lethal or toxic effects. Mice (strain BALB/c, females) are used as experimental animals. EFFECT: enhanced adjuvant activity of compound. 1 ex, 1 tbli