DERIVATIVES OF QUINOLINE- OR NAPHTHYRIDINE CARBOXYLIC ACID AND METHODS OF THEIR SYNTHESIS

FIELD: organic chemistry. SUBSTANCE: invention relates to new derivative of quinoline (naphthyridine) carboxylic acid of the formula (I) $$$ that has 4-aminomethyl- -3-oximepyrrolidine substitute at position 7 of quinolone ring and shows high antibacterial activity as compared with the known quinolo...

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Hauptverfasser:	DZHEONG IN OKH, JANG KVAN KIM, SE. KHO KIM, MU IONG KIM, DZHEJ KHEK CHANG, DO KHJUN NAM, JIDZHEONG, CHANG JONG KHONG, KHUN CHOJ, DZHIN KHVAN KVAK
Format:	Patent
Sprache:	eng ; rus
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	FIELD: organic chemistry. SUBSTANCE: invention relates to new derivative of quinoline (naphthyridine) carboxylic acid of the formula (I) $$$ that has 4-aminomethyl- -3-oximepyrrolidine substitute at position 7 of quinolone ring and shows high antibacterial activity as compared with the known quinolone antibacterial agents of low activity against gram-positive bacterial strains. Compound of the formula (I) has R, $$$ and Q that are similar to indicated in description. The synthesized derivatives show also broad antibacterial spectrum and very improved pharmacokinetic properties. EFFECT: enhanced effectiveness of compounds. 11 cl, 27 tbl, 202 ex