1,4-DISUBSTITUTED PIPERAZINES USEFUL FOR TREATMENT OF PATIENTS WITH ASTHMA AND RESPIRATORY WAY INFLAMMATION, METHOD OF THEIR SYNTHESIS, DRUGS BASED ON THEREOF AND A METHOD OF PREPARING

FIELD: organic chemistry and chemical technology. SUBSTANCE: invention relates to 1,4-disubstituted piperazines of the general formula (I) where B means group -CO- or CH2--OCO; D means heteroaryl taken from 1,3,5-triazinyl, pyrimidinyl and pyridinyl possibly substituted with one or two substituents taken from mono-(C1-C6)-alkylamino-, mono-(C3-C7)-alkenylamino-, di-(C1-C6)-alkylamino-, (C1-C6)-alkyl-(C3-C7)-alkenylamino- and pyrrolidine-1-yl-group; Ra and Rb mean hydrogen atom or (C1-C3)-alkyl; n is a whole number from 1 to 4; their enantiomers, racemic mixtures and their salts with pharmaceutically acceptable acids and bases. Method of synthesis of compounds of the formula (I) involves interaction of compound of the formula (II) with compound of the formula (III) and obtaining the compound of the formula (Ia) that are converted to compounds of the formula (I) by conversion of -COOR-group to -COOH-group. Invention relates to also drug used for decrease the enhanced bronchial reactivity that has an effective amount of compound of the formula (I) as an active component and a method of its preparing. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 10 cl, 15 ex, 1 tbli