METHOD OF INDUSTRIAL PRODUCING THE HUMAN LEUKOCYTE INTERFERON-ALPHA-2

FIELD: biotechnology. SUBSTANCE: strain Escherichia coli SG 20050/pIF is grown on 2B-medium at the rate of rotating device 12-15 rev/min and aeration intensity 0.5-0.8 l/h. Polypeptide accumulation is (2.4-4.1) x 10 IU/ml. Method can be used for industrial production of the human recombinant interfe...

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Hauptverfasser:	NAUMOVA N.V, PIKALOVA M.I, KOLOKOL'TSOV A.A, KHAJBULLINA I.I, OSTAPENKO E.V, GORINA G.I, DOMANOVA Z.M, JUDINA I.V
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology. SUBSTANCE: strain Escherichia coli SG 20050/pIF is grown on 2B-medium at the rate of rotating device 12-15 rev/min and aeration intensity 0.5-0.8 l/h. Polypeptide accumulation is (2.4-4.1) x 10 IU/ml. Method can be used for industrial production of the human recombinant interferon-alpha-2. EFFECT: improved method of producing, increased yield. 4 tbl, 4 exv