DERIVATIVES OF TRIAZOLO[1,4]DIAZEPINE AND METHODS OF THEIR SYNTHESIS
FIELD: organic chemistry and technology. SUBSTANCE: invention describes derivatives of triazolo[1,4] diazepine of the formulas (I) R , (II) R and (III) R and their pharmacological salts where R and - H or alkyl; R - halogen; - lower alkyl; X - group of the formulas -OCO-, where - H or lower alkyl, -...
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| creator | ESINORI SAKUMA RICHARD STEFEN DZHON KLARK KAZUO OKANO SUKHEI MIJAZAVA NAOJUKI SIMOMURA ESIMASA MATIDA KOUKITI KHARADA OSAMU ASANO KOUITI KATAJAMA ISAO JAMATSU MITSUAKI MIJAMOTO KOUDZI JAMADA KENZO MURAMOTO KHADZIME TSUNODA KHIROSI OBAISI SATOSI KATAJAMA KHIROJUKI ESIMURA SIGERU SOUDA SINIA ABE TETSUJA KAVAKHARA |
| description | FIELD: organic chemistry and technology. SUBSTANCE: invention describes derivatives of triazolo[1,4] diazepine of the formulas (I) R , (II) R and (III) R and their pharmacological salts where R and - H or alkyl; R - halogen; - lower alkyl; X - group of the formulas -OCO-, where - H or lower alkyl, -CO- or other groups and Y - cycloalkyl, cycloalkylalkyl, alkynyl or other groups. Derivatives of diazepine I-III inhibit platelet activation factor and exhibit the prolonged effect of activity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 11 cl, 146 ex, 1 tbl, 1 dwg |
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SUBSTANCE: invention describes derivatives of triazolo[1,4] diazepine of the formulas (I) R , (II) R and (III) R and their pharmacological salts where R and - H or alkyl; R - halogen; - lower alkyl; X - group of the formulas -OCO-, where - H or lower alkyl, -CO- or other groups and Y - cycloalkyl, cycloalkylalkyl, alkynyl or other groups. Derivatives of diazepine I-III inhibit platelet activation factor and exhibit the prolonged effect of activity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 11 cl, 146 ex, 1 tbl, 1 dwg</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DERIVATIVES OF TRIAZOLO[1,4]DIAZEPINE AND METHODS OF THEIR SYNTHESIS |
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