DERIVATIVES OF TRIAZOLO[1,4]DIAZEPINE AND METHODS OF THEIR SYNTHESIS

DERIVATIVES OF TRIAZOLO[1,4]DIAZEPINE AND METHODS OF THEIR SYNTHESIS

FIELD: organic chemistry and technology. SUBSTANCE: invention describes derivatives of triazolo[1,4] diazepine of the formulas (I) R , (II) R and (III) R and their pharmacological salts where R and - H or alkyl; R - halogen; - lower alkyl; X - group of the formulas -OCO-, where - H or lower alkyl, -...

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Hauptverfasser: ESINORI SAKUMA, RICHARD STEFEN DZHON KLARK, KAZUO OKANO, SUKHEI MIJAZAVA, NAOJUKI SIMOMURA, ESIMASA MATIDA, KOUKITI KHARADA, OSAMU ASANO, KOUITI KATAJAMA, ISAO JAMATSU, MITSUAKI MIJAMOTO, KOUDZI JAMADA, KENZO MURAMOTO, KHADZIME TSUNODA, KHIROSI OBAISI, SATOSI KATAJAMA, KHIROJUKI ESIMURA, SIGERU SOUDA, SINIA ABE, TETSUJA KAVAKHARA
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:FIELD: organic chemistry and technology. SUBSTANCE: invention describes derivatives of triazolo[1,4] diazepine of the formulas (I) R , (II) R and (III) R and their pharmacological salts where R and - H or alkyl; R - halogen; - lower alkyl; X - group of the formulas -OCO-, where - H or lower alkyl, -CO- or other groups and Y - cycloalkyl, cycloalkylalkyl, alkynyl or other groups. Derivatives of diazepine I-III inhibit platelet activation factor and exhibit the prolonged effect of activity. EFFECT: improved method of synthesis, enhanced effectiveness of compounds synthesized. 11 cl, 146 ex, 1 tbl, 1 dwg