2-SACCHARINYLMETHYLARYL CARBOXYLATES, METHOD OF PREPARING THEREOF (VARIANTS), AND COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYME
FIELD: biological industry. SUBSTANCE: 2-saccharinylmethylaryl carboxylates are prepared by reacting halomethylsaccharin with suitable acid or salt thereof. Second method comprises reacting saccharin with alkylcarboxylic acid chloromethyl ester to obtain 4-isopropyl-6-methoxy-2-saccharinylmethyl-2,6...
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| creator | RICHARD POL' DANLEHP VAJRINDRA KUMAR CHAKRAPANI SUBRAMANIAM DEHNNIZ DZHON LASTA DZHON DZHOZEF KURT NEJL UORREN BOUZ MEHLKOL'M RAJS BEHLL EHBERT DZHOZEF M'JURE RANZHIT CHIMANLAL DESAI MANOKHAR TUKRAM SEHJNDEHJN |
| description | FIELD: biological industry. SUBSTANCE: 2-saccharinylmethylaryl carboxylates are prepared by reacting halomethylsaccharin with suitable acid or salt thereof. Second method comprises reacting saccharin with alkylcarboxylic acid chloromethyl ester to obtain 4-isopropyl-6-methoxy-2-saccharinylmethyl-2,6- dichloro-3-carboxymethylaminosulfonyl benzoate, yield is 45% and m.p. is 204-206 C. Compounds inhibit activity of proteolytic enzymes. EFFECT: improved properties of proteolytic enzymes. 16 cl, 15 tble |
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SUBSTANCE: 2-saccharinylmethylaryl carboxylates are prepared by reacting halomethylsaccharin with suitable acid or salt thereof. Second method comprises reacting saccharin with alkylcarboxylic acid chloromethyl ester to obtain 4-isopropyl-6-methoxy-2-saccharinylmethyl-2,6- dichloro-3-carboxymethylaminosulfonyl benzoate, yield is 45% and m.p. is 204-206 C. Compounds inhibit activity of proteolytic enzymes. EFFECT: improved properties of proteolytic enzymes. 16 cl, 15 tble</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-SACCHARINYLMETHYLARYL CARBOXYLATES, METHOD OF PREPARING THEREOF (VARIANTS), AND COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYME |
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