2-SACCHARINYLMETHYLARYL CARBOXYLATES, METHOD OF PREPARING THEREOF (VARIANTS), AND COMPOSITION INHIBITING ACTIVITY OF PROTEOLYTIC ENZYME

FIELD: biological industry. SUBSTANCE: 2-saccharinylmethylaryl carboxylates are prepared by reacting halomethylsaccharin with suitable acid or salt thereof. Second method comprises reacting saccharin with alkylcarboxylic acid chloromethyl ester to obtain 4-isopropyl-6-methoxy-2-saccharinylmethyl-2,6...

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Hauptverfasser:	RICHARD POL' DANLEHP, VAJRINDRA KUMAR, CHAKRAPANI SUBRAMANIAM, DEHNNIZ DZHON LASTA, DZHON DZHOZEF KURT, NEJL UORREN BOUZ, MEHLKOL'M RAJS BEHLL, EHBERT DZHOZEF M'JURE, RANZHIT CHIMANLAL DESAI, MANOKHAR TUKRAM SEHJNDEHJN
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	FIELD: biological industry. SUBSTANCE: 2-saccharinylmethylaryl carboxylates are prepared by reacting halomethylsaccharin with suitable acid or salt thereof. Second method comprises reacting saccharin with alkylcarboxylic acid chloromethyl ester to obtain 4-isopropyl-6-methoxy-2-saccharinylmethyl-2,6- dichloro-3-carboxymethylaminosulfonyl benzoate, yield is 45% and m.p. is 204-206 C. Compounds inhibit activity of proteolytic enzymes. EFFECT: improved properties of proteolytic enzymes. 16 cl, 15 tble