STRAIN OF HYBRID CULTURED MAMMALIAN CELLS MUS MUSCULUS L - A PRODUCER OF MONOCLONAL ANTIBODIES SHOWING SPECIFICITY TO BRUCELLA PROTEIN PREPARATION OF MOLECULAR MASS 18 AND 38 KDA

FIELD: biotechnology, medicine. SUBSTANCE: strain is obtained by hybridization of murine splenocytes of line BALB/c immunized with brucella cells killed by heating. Strain produces monoclonal antibodies (MCA) of isotype IgG. They show specificity to brucella protein preparation of molecular mass 18...

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Hauptverfasser:	ZAKHLEBNAJA O.D, MIKHAJLOV L.M, TITENKO A.M, LAUKNER I.V
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	FIELD: biotechnology, medicine. SUBSTANCE: strain is obtained by hybridization of murine splenocytes of line BALB/c immunized with brucella cells killed by heating. Strain produces monoclonal antibodies (MCA) of isotype IgG. They show specificity to brucella protein preparation of molecular mass 18 and 38 kDa prepared by method of genetic engineering. Titers of MCA in cultural and ascitic fluids are 1:160 and 1:128 000, respectively. MCA can be used for brucellosis diagnosis. EFFECT: enhanced specificity of monoclonal antibodies. 2 tbl, 1 exo