METHOD OF SYNTHESIS OF 4-ETHYL-2,6,7-TRIOXA-1-PHOSPHOBICYCLO-[2,2,2]-OCTANE-1-OXIDE HIGHLY LABELED WITH TRITIUM OR DEUTERIUM AT ETHYL RADICAL

METHOD OF SYNTHESIS OF 4-ETHYL-2,6,7-TRIOXA-1-PHOSPHOBICYCLO-[2,2,2]-OCTANE-1-OXIDE HIGHLY LABELED WITH TRITIUM OR DEUTERIUM AT ETHYL RADICAL

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to new substance - 4-ethyl-2,6,7-trioxa-1-phosphobicyclo-[2.2.2]-octane-1-oxide highly labeled with tritium or deuterium at ethyl radical. The parent compound is subjected for reaction of catalytic solid-phase heterogeneous isotope...

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Bibliographische Detailangaben
Hauptverfasser: SHEVCHENKO V.P, MJASOEDOV N.F, NAGAEV I.JU, FARADZHEVA S.V
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to new substance - 4-ethyl-2,6,7-trioxa-1-phosphobicyclo-[2.2.2]-octane-1-oxide highly labeled with tritium or deuterium at ethyl radical. The parent compound is subjected for reaction of catalytic solid-phase heterogeneous isotope exchange between substance hydrogens and gaseous tritium. Reaction of isotope exchange is carried out for 15-25 min at 160-180 C using 5% Pt/C as a catalyst. Ratio of catalyst and substance = (8-12):1. Synthesized compound can be used in chemistry of physiologically active compounds in medical-biological investigations. EFFECT: improved method of synthesis.