ISOINDOLONE DERIVATIVES OR THEIR SALTS WITH ACIDS AS INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDS - PERHYDROISOINDOLONES

FIELD: organic chemistry. SUBSTANCE: products: derivatives of isoindolone of the formula (I) $$$ where R means hydrogen atoms or form bond together; R' means hydrogen atom, allyl or radical of the formula -C-$$$ where $$$ and $$$ means hydrogen or phenyl possibly substituted with halogen, alkyl...

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Hauptverfasser: MARI-KRISTIN DJUBREK, ZHAN-FRANSUA PEJRONEL, MISHEL' TABAR, KLOD MUTONN'E, ALAN TRJUSHON
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creator MARI-KRISTIN DJUBREK
ZHAN-FRANSUA PEJRONEL
MISHEL' TABAR
KLOD MUTONN'E
ALAN TRJUSHON
description FIELD: organic chemistry. SUBSTANCE: products: derivatives of isoindolone of the formula (I) $$$ where R means hydrogen atoms or form bond together; R' means hydrogen atom, allyl or radical of the formula -C-$$$ where $$$ and $$$ means hydrogen or phenyl possibly substituted with halogen, alkyl, alkylhydroxy- or nitro-group; $$$ has values $$$ and $$$ or means alkyl or alkylhydroxyalkyl being at least one of $$$ and $$$ means free or substituted phenyl; radicals R'' are similar and mean phenyl radicals as (3aR, 7aR) or as a mixture of forms (3aRS, 7aRS), or their salts with acids. Reagent 1: compound of the formula R'-$$$. Reagent 2: derivative of cyclohexenone of the formula (II) $$$ where R, R' and R'' have above indicated values. Reaction conditions: in the presence of catalytic amount of oxygen in organic solvent. EFFECT: improved method of synthesis. 3 tbl
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ISOINDOLONE DERIVATIVES OR THEIR SALTS WITH ACIDS AS INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF BIOLOGICALLY ACTIVE COMPOUNDS - PERHYDROISOINDOLONES
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