CEPHALOSPORIN COMPOUNDS, THEIR PHARMACEUTICALLY ACCEPTABLE NONTOXIC SALTS, PHYSIOLOGICALLY HYDROLYZABLE ESTERS, ISOMERS HAVING E-CONFIGURATION OF DOUBLE BOND IN PROPENYL GROUP, SYN-ISOMERS AND OPTICAL ISOMERS AND A METHOD OF THEIR SYNTHESIS

The present invention relates to a cephalosporin compound represented by the following general formula (I) : its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, in which R represents hydrogen or an amino-protecting group, R and...

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Hauptverfasser: CHAN SIK BANG, JONG TSU KIM, DEOG KHO YANG, KHUN SEUNG OKH, SE KHO KIM, DZHAE KHUN DZHEON, DZHAE KHONG JEO, JUNG MIN VU, SAM SIK KIM, DZHONG CHAN LIM, TAE KHI LI, MU JONG KIM
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a cephalosporin compound represented by the following general formula (I) : its pharmaceutically acceptable non-toxic salt, physiologically hydrolyzable ester, hydrate or solvate, or isomers thereof, in which R represents hydrogen or an amino-protecting group, R and R can be identical or different and independently of one another represent hydrogen or a hydroxy-protecting group, or R and R together can form a cyclic diol-protecting group, R represents hydrogen or a carboxyl-protecting group, R , R and R independently of one another represent hydrogen, amino or substituted amino, hydroxy, alkoxy, C1-4 alkyl, carboxyl or alkoxycarbonyl, or R and R together with the carbon atoms to which they are attached can form a C3-7 cycle, and Q represents CH or N, and to a process for preparation thereof and a pharmaceutical composition containing the compound (I) as an active ingredient.