ARYLSULFONEAMIDE DERIVATIVES, MIXTURES OF THEIR ISOMERS OR INDIVIDUAL ISOMERS AND THEIR PHYSIOLOGICALLY TOLERANTABLE ADDITIVE SALTS WITH BASES AND PHARMACEUTICAL COMPOSITION SHOWING ANTITHROMBIC ACTIVITY

The present invention relates to novel arylsulphonamides of the formula in which A, B and R1 to R6 are as defined in Claim 1, their enantiomers, their cis- and trans-isomers, if R4 and R5 together represent a carbon-carbon bond, and their addition salts, in particular, for pharmaceutical use, their...

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Hauptverfasser:	ZOJKA RAJNER, VAJZENBERGER JOKHANNES, NIKL JOZEF, AJZERT VOLFGANG, MID KRISTOFER, MUATSEVICH GOJKO, MYULLER TOMAS, KHEKEL ARMIN
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to novel arylsulphonamides of the formula in which A, B and R1 to R6 are as defined in Claim 1, their enantiomers, their cis- and trans-isomers, if R4 and R5 together represent a carbon-carbon bond, and their addition salts, in particular, for pharmaceutical use, their physiologically tolerable addition salts with inorganic or organic bases, if R6 represents a hydroxyl group, which have valuable pharmacological properties, in particular antithrombotic effects and effects mediated by thromboxane. At the same time, the novel compounds are additionally thromboxane antagonists (TRA) and thromboxane synthesis inhibitors (TSI). In addition, they also have an effect on PGE2 production.