N-PHENYL-2-CYANO-3-HYDROXYCROTONIC ACID AMIDE, METHOD OF ITS SYNTHESIS AND DRUG SHOWING ANTIINFLAMMATORY ACTIVITY WITH RESPECT TO RHEUMATIC DISEASE, AUTOIMMUNE DISEASE OR REJECTION RESPONSE OF RECIPIENT TRANSPLANTABLE ORGAN

The use of N-phenyl-2-cyano-3-hydroxycrotonamide derivatives of the formula I where R is hydrogen atom or (C1-C4)-alkyl, R is CN, CX3, WCX3, W(CH2)nCX3, NO2, (CH2)nCX3, halogen, in which X is halogen, W is oxygen or sulphur atom and n is an integer from 1 to 3, R is (C1-C4)-alkyl, (C3-C6)-cycloalkyl, CN or -CO-R in which R is (C1-C4)-alkyl or (C3-C6)-cycloalkyl, and/or the physiologically tolerated salts thereof, for the treatment of rheumatic disorders, autoimmune diseases and of rejection reactions against the transplanted organ in an organ recipient, is described.