METHOD OF SYNTHESIS OF DERIVATIVES OF O-(2-HYDROXY-3-PIPERIDINO-1-PROPYL)-NICOTINIC ACID AMIDEOXIME AND THEIR SALTS (VARIANTS), O-(2-HYDROXY-3-PIPERIDINO-1-PROPYL)-NICOTINIC ACID AMIDEOXIME PURE CRYSTALLINE BASE

METHOD OF SYNTHESIS OF DERIVATIVES OF O-(2-HYDROXY-3-PIPERIDINO-1-PROPYL)-NICOTINIC ACID AMIDEOXIME AND THEIR SALTS (VARIANTS), O-(2-HYDROXY-3-PIPERIDINO-1-PROPYL)-NICOTINIC ACID AMIDEOXIME PURE CRYSTALLINE BASE

A pure crystalline O-(2-hydroxy-3-piperidino-1-propyl) nicotinic acid amidoxime base of the Formula (Ib) (* CHEMICAL STRUCTURE *) is disclosed characterized by a melting point of 70 degrees to 73 degrees C., giving, when dissolved in an amount of 1 to 10 ml of concentrated sulfuric acid, a yellow ho...

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Bibliographische Detailangaben
Hauptverfasser: ISHTVAN SEKELI, SHANDOR BOTAR, BELA BERTOK, LAJOSH NAD, ANGELIKA TURNER, KALMAN TAKACH, EVA SHOMFAI, ANTAL GAJARI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A pure crystalline O-(2-hydroxy-3-piperidino-1-propyl) nicotinic acid amidoxime base of the Formula (Ib) (* CHEMICAL STRUCTURE *) is disclosed characterized by a melting point of 70 degrees to 73 degrees C., giving, when dissolved in an amount of 1 to 10 ml of concentrated sulfuric acid, a yellow homogeneous solution, and showing the following spectral characteristics: IR spectrum (kBr): (gamma) -O-C=N 1642 cm-1 1H-NMR spectrum (CDCL3, (delta) ppm): 1.48 m, (6H), CH2-piperidine; 2.42 m, (6H), 3*CH2-N; 3.36, br, (1H), CH-O; 4.08 m, (3H), 1-CH2, OH; 5.2, br, (2H), NH2; 7.30 m (1H), pyridine-5'; 7.92 m, 4', 8.62 m (1H), 6', 8.88 m, (1H), 2'.