(4-AMINO-2,6-DIMETHYLPHENYL SULFONYL)NITROMETHANE PHENYL ACETYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

(4-AMINO-2,6-DIMETHYLPHENYL SULFONYL)NITROMETHANE PHENYL ACETYL DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effect...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LINDA SLEJTER, DEVID ROBERT BRITTEJN, ENTONI LOREN KUPER, DZHON PRESTON, STIVEN POL BRAUN, DZHETRO LOURENS LONGRIDZH, DZHEFFRI DZHEJMS MORRIS
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention concerns novel N-phenylacetyl and related acyl derivatives of (4-amino-2,6-dimethylphenylsulphonyl)nitromethane and pharmaceutically acceptable salts thereof which are inhibitors of the enzyme aldose reductase and are of value, for example, in the treatment of certain peripheral effects of diabetes and galactosemia. Also disclosed are pharmaceutical compositions containing one of the derivatives and processes for the manufacture and use of the derivatives.