METHOD FOR HYDROLYSIS OF AMINO ACID CONSEQUENCE OF FORERUNNER OF INSULIN AT HUMAN

A process for the specific hydrolysis of the amino-acid chain of preproinsulins to give the corresponding intermediates with the aid of clostripain is described, and these intermediates can be converted where appropriate with carboxypeptidase B into the corresponding insulins.

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Bibliographische Detailangaben
Hauptverfasser: JOKHANNES MAJVES, MIKHAEL DERSHUG, KLAUS-PETER KOLLER, RYUDIGER MARKVARDT
Format: Patent
Sprache:eng
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Zusammenfassung:A process for the specific hydrolysis of the amino-acid chain of preproinsulins to give the corresponding intermediates with the aid of clostripain is described, and these intermediates can be converted where appropriate with carboxypeptidase B into the corresponding insulins.