METHOD OF SYNTHESIS OF 1 BETA-ETHYL-1 ALPHA-(HYDROXYMETHYL)-1,2,3,4,6,7,12,ALPHA-OCTAHYDRO- INDOLE(2,3-A)QUINOLIZINE (VARIANTS), 1-ETHYL-1-(HYDROXYMETHYL)- 1,2,3,4,6,7-HEXAHYDRO-12H-INDOLE(2,3-A)QUINOLIZINE AND ITS OPTICALLY ACTIVE SALTS

METHOD OF SYNTHESIS OF 1 BETA-ETHYL-1 ALPHA-(HYDROXYMETHYL)-1,2,3,4,6,7,12,ALPHA-OCTAHYDRO- INDOLE(2,3-A)QUINOLIZINE (VARIANTS), 1-ETHYL-1-(HYDROXYMETHYL)- 1,2,3,4,6,7-HEXAHYDRO-12H-INDOLE(2,3-A)QUINOLIZINE AND ITS OPTICALLY ACTIVE SALTS

PCT No. PCT/HU91/00046 Sec. 371 Date Jun. 25, 1992 Sec. 102(e) Date Jun. 25, 1992 PCT Filed Oct. 30, 1991 PCT Pub. No. WO92/07851 PCT Pub. Date May 14, 1992.The invention relates to a novel process for the preparation of (-) -1 beta -ethyl-1 alpha -(hydroxymethyl) - 1,2,3,4,6,7,12,12b alpha -octahyd...

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Hauptverfasser: YUDIT BRILL, D"ERD VISHKI, MARIYA FARKASH, IDA DOJCH, KATALIN NOGRADI, LASLO TSIBULA, YANOSH KRAJDL
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:PCT No. PCT/HU91/00046 Sec. 371 Date Jun. 25, 1992 Sec. 102(e) Date Jun. 25, 1992 PCT Filed Oct. 30, 1991 PCT Pub. No. WO92/07851 PCT Pub. Date May 14, 1992.The invention relates to a novel process for the preparation of (-) -1 beta -ethyl-1 alpha -(hydroxymethyl) - 1,2,3,4,6,7,12,12b alpha -octahydro-indolo[2,3-a]quinolizine of the formula (I) (I) and to novel intermediates obtained in this process. The compound of the formula (I) prepared by the process of the invention possesses a peripheral vasodilator effect.