METHOD OF SYNTHESIS OF 6,7-DICHLORO-1,5-DIHYDROIMIDAZO-(2,1-B)-QUINAZOLINE-2-(3H)-ONE, INTERMEDIATES FOR THEIR SYNTHESIS AND A METHOD OF THEIR SYNTHESIS

METHOD OF SYNTHESIS OF 6,7-DICHLORO-1,5-DIHYDROIMIDAZO-(2,1-B)-QUINAZOLINE-2-(3H)-ONE, INTERMEDIATES FOR THEIR SYNTHESIS AND A METHOD OF THEIR SYNTHESIS

A subject matter of the invention is a process for the preparation of 6,7-di-(chloro)-1,5-di-(hydro)-imidazo[2,1-b]quinazolin-2[3H]-one of formula or a salt thereof including their hydrates, characterized by subjecting [2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl] -acetonitr...

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Hauptverfasser: PETER SHLEGEL, AGNESH KHALBAUER, SVETLANA ZHARNOTSAI, MARIA KIRAJ, YANOSH BRLIK, FRIDESH GERGENI, MARGIT CHERGO, MAGDOLNA KENERESH, DEZHE DANI, GABOR GIGLER, ILONA STRUKHAR, PETER TOMPE, PETER TRINKA, PAL FEKETE, SHAROLTA BENKO, JOZHEF RAJTER, EVA SABO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:A subject matter of the invention is a process for the preparation of 6,7-di-(chloro)-1,5-di-(hydro)-imidazo[2,1-b]quinazolin-2[3H]-one of formula or a salt thereof including their hydrates, characterized by subjecting [2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl] -acetonitrile or a /2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl/ -acetic acid alkylester of the general formula wherein R' stands for a cyano group or a group of the formula in which latter R1 represents a straight or branched alkyl group having from 1 to 6 carbon atom(s), optionally carrying a phenyl substituent, to thermic cyclization in an acidic medium. Further subject matters of the invention are [2-(cyanoimino)-5,6-di-(chloro)-1,2,3,4-tetra-(hydro)-quinazolin-3-yl] -acetonitriles or -acetic acid alkylesters of the general formula wherein R' is as defined above, useful as intermediates in the said process and a process for preparing them.