N-ALKYL DERIVATIVES OF ANTIBIOTICS OR THEIR PHARMACEUTICALLY AVAILABLE SALTS HAVING ANTIFUNGOUS ACTIVITY AS INTERMEDIATE COMPOUND IN SYNTHESIS OF N-ALKYL DERIVATIVES OF ANTIBIOTICS, METHOD FOR PRODUCTION OF N-ALKYL DERIVATIVES OF ANTIBIOTICS OR THEIR PHARMACEUTICALLY AVAILABLE SALTS

Disclosed herein are N-alkyl derivatives (II) of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents. wherein R is H, or R is methyl and the resulting alanyl is D-alanyl; R is H or beta -D-xylosyl; and Y...

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Bibliographische Detailangaben
Hauptverfasser:	TOSIKAZU OKI, MASATOSI KAKUSIMA, MASATAKA KONISI, MAKI NISIO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed herein are N-alkyl derivatives (II) of antibiotics BU-3608, BU-3608 B, C, D and E as well as the corresponding desxylosyl compounds. These novel compounds are useful as antifungal agents. wherein R is H, or R is methyl and the resulting alanyl is D-alanyl; R is H or beta -D-xylosyl; and Y is NR R or NR R R X; wherein R , R and R are the same or different C1-5alkyl; and X is an anion; or a pharmaceutically acceptable salt thereof.