DERIVATIVES OF ACRYLIC ACID AMIDE OR THEIR SALTS WITH ORGANIC OR INORGANIC BASE SHOWING CYTOPROTECTIVE AND ANTIULCER ACTIVITIES, AND A COMPOSITION SHOWING CYTOPROTECTIVE AND ANTIULCER ACTIVITIES

Novel acrylic amide derivative of the formula wherein R represents a hydrogen or a halogen atom or a C1-4alkyl, a C1-4alkoxy or a nitro group. n is an integer of 0 to 2, A represents an amino acid residue derived from a naturally occuring amino acid or an antipode thereof which is connected to the a...

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Hauptverfasser: DOBAI LASLO, FODOR TAMASH, SPORNI LASLO, FISHER YANOSH, EZER ELEMER, MATUZ YUDIT, SHAGI KATALIN, KHAJOSH DERD
Format: Patent
Sprache:eng
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Zusammenfassung:Novel acrylic amide derivative of the formula wherein R represents a hydrogen or a halogen atom or a C1-4alkyl, a C1-4alkoxy or a nitro group. n is an integer of 0 to 2, A represents an amino acid residue derived from a naturally occuring amino acid or an antipode thereof which is connected to the acrylic acyl residue through its amino group; or a residue derived from thiazolidinecarboxylic acid connected to the acrylic acyl group through its nitrogen, or a derivative of the above residues wherein any free carboxy group is esterified with a C1-4alkyl group or is amidated; or A represents a group of formula wherein R2 is a hydrogen atom or a phenyl, a C1-4alkyl or a C1-4alkoxycarbonyl group, and their salts which have interesting cytoprotective and antiulcer activities are provided. A process is also described for the preparation of said compounds.