PROCESS FOR PREPARING 3-(S)-(-)- (1-CARBAMOYL-1,1- DIPHENYLMETHYL)-1-[2- (2,3-DIHYDROBENZOFURAN-5-YL) ETHYL] PYRROLIDINE OR SALT THEREOF

PROCESS FOR PREPARING 3-(S)-(-)- (1-CARBAMOYL-1,1- DIPHENYLMETHYL)-1-[2- (2,3-DIHYDROBENZOFURAN-5-YL) ETHYL] PYRROLIDINE OR SALT THEREOF

Pyrrolidine muscarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of the formula:- and their pharmaceutically acceptable salts, wherein Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-; R is -CN or -CONH2; and R is a group of the formula:- where X an...

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Bibliographische Detailangaben
Hauptverfasser: PITER EDVARD KROSS, ALEKSANDR RODERIK MAKKENZI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Pyrrolidine muscarinic receptor antagonists, particularly useful in the treatment of irritable bowel syndrome, of the formula:- and their pharmaceutically acceptable salts, wherein Y is a direct link, -CH2-, -(CH2)2-, -CH2O- or -CH2S-; R is -CN or -CONH2; and R is a group of the formula:- where X and X are each independently O or CH2; m is 1, 2 or 3; and "Het" is pyridyl, pyrazinyl or thienyl. u