METHOD OF PRODUCING DERIVATIVES OF OXADIAZOLALKYLPURINE OR ITS PHARMACEUTICALLY AVAILABLE ACID ADDITIVE SALTS ( AND VARIANTS OF THIS METHOD )

METHOD OF PRODUCING DERIVATIVES OF OXADIAZOLALKYLPURINE OR ITS PHARMACEUTICALLY AVAILABLE ACID ADDITIVE SALTS ( AND VARIANTS OF THIS METHOD )

The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in wh...

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Bibliographische Detailangaben
Hauptverfasser: DEZHE KARBONITSH, KATALIN MARMAROSHI, EMIL MINKER, GABOR KOVACH, LORAND DEBRETSENI, AGNESH GOTTSHEGEN, ZOLTAN VARGAI, GERGELI KHEJA, IENE MARTON, SHANDOR VIRAG, LASLO TARDOSH, ANDREA BOLEKHOVSKI, PETER KERMETSI, SHANDOR ANTUSH, VERA GERGELI, GABOR KHORVAT
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to new oxidiazole-alkyl-purine-derivatives of the Formula I and pharmaceutically acceptable salts thereof wherein A stands for C1-4 alkylene and R1 represents C1-6 alkyl, hydroxyalkyl, halogenoalkyl, carboxyalkyl, C5-6 cycloalkyl or aminoalkyl of the Formula -(CH2)n-NR2R3 in which group n is an integer 1-3; R2 and R3 each stand for hydrogen or C1-4 alkyl or together with the adjacent nitrogen atom they are attached to form a 5- or 6-membered nitrogen containing heterocyclic ring which may optionally comprise a further nitrogen atom or an oxygen atom as heteroatom; or R1 stands for phenyl, hydroxyphenyl, carboxyphenyl, benzyl or dimethoxybenzyl The compounds of the Formula I can be prepared by methods known per se and can be used in therapy as antitussive agents.